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Group Jonas Nilsson

Sahlgrenska Translational Melanoma Group (SATMEG)

Research Summary

We try to identify new means to treat cancer based on our previous research on the oncogenic transcription factor c-Myc. This research has pointed on potential targets for anti-cancer drugs including kinases, epigenetic readers and metabolic enzymes.
Recently the group's activities has shifted into translating the knowledge gained from the Myc research into melanoma. Myc is overexpressed in melanoma so therefore its expression is not an optimal biomarker to define which of our previously identified targets would be viable in melanoma. Our new research therefore seek to identify biomarkers of response to new targeted therapies.
The research has generated the framework of starting the Sahlgrenska Translational Melanoma Group (SATMEG), consisting of basic researchers and clinical investigators working together to devise new therapies against melanoma. Read more about SATMEG activities here:


Current Group Members

Jonas Nilsson, PhD, Group leader at Sahlgrenska Cancer Center and Professor of Experimental Cancer Surgery
Phone: +46 (0)31 786 6768
E-mail: jonas.a.nilsson@surgery.gu.se

Roger Olofsson, MD, PhD, Consultant surgeon
Jan Mattson, MD, PhD, Consultant surgeon
Valerio Belgrano, MD, PhD student

Medical Oncologists:
Lars Ny, MD, PhD, Associate professor and Consultant oncologist
Ulrika Stierner, MD, PhD, Consultant oncologist
Henrik Jespersen, MD, Resident in Oncology, PhD student

Senior Research Fellows:
Lisa Nilsson, PhD, Senior staff scientist
Lydia Green, PhD, Postdoctoral fellow
Mattias Lindberg, PhD, Postdoctoral fellow
Paul-Steffen Kuhn, PhD, Postdoctoral fellow

Post-graduate students:
Berglind Einarsdottir, MSc, PhD student
Joydeep Bhadury, MSc, PhD student
Somsundar Veppil Muralidharan, MSc, PhD student
Elin Söderberg, MSc, PhD student

Technical staff:
Sofia Nordstrand, animal technician

Selected Publications

  1. Nilsson LM, Green LC, Muralidharan SV, Demir D, Welin M, Bhadury J, Logan D, Walse B, Nilsson JA (2016) Cancer differentiation agent hexamethylene bisacetamide was likely the first BET bromodomain inhibitor in clinical trials. Cancer Res, epub ahead of print
  2. Muralidharan SV, Bhadury J, Nilsson LM, Green LC, McLure KG and Nilsson JA. (2016) BET bromodomain inhibitors synergize with ATR inhibitors to induce DNA damage, apoptosis, senescence-associated secretory pathway and ER stress in Myc-induced lymphoma cells. Oncogene, epub ahead of print
  3. Panda S, Nilsson JA and Gekara NO. Deubiquitinase MYSM1 regulates innate immunity through inactivation of TRAF3 and TRAF6 complexes. (2015) Immunity 43:647-659. IF 21
  4. Le Gal K, Ibrahim MX, Wiel C, Sayin VI, Akula MK, Karlsson C, Dalin MG, Akyürek LM, Lindahl P, Nilsson J, Bergo MO. Antioxidants can increase melanoma metastasis in mice. (2015) Sci Transl Med. 8:308re8. IF 18
  5. DNA damage primes the type I interferon system via the cytosolic DNA sensor STING to promote anti-microbial innate immunity. Härtlova A, Erttmann SF, Raffi FA, Schmalz AM, Resch U, Anugula S, Lienenklaus S, Nilsson LM, Kröger A, Nilsson JA, Ek T, Weiss S, GekaraNO. Immunity. 2015 42(2):332-43
  6. Systematic analysis of noncoding somatic mutations and gene expression alterations across 14 tumor types. 
Fredriksson NJ, Ny L, Nilsson JA, Larsson E. 
Nat Genet. 2014

  7. Melanoma patient-derived xenografts accurately model the disease and develop fast enough to guide treatment decisions.
Einarsdottir BO, Bagge RO, Bhadury J, Jespersen H, Mattsson J, Nilsson LM, Truvé K, López MD, Naredi P, Nilsson O, Stierner U, Ny L, Nilsson JA. 
Oncotarget 2014:5(20):9609-18.

  8. BET and HDAC inhibitors induce similar genes and biological effects and synergize to kill in Myc-induced murine lymphoma.
Bhadury J, Nilsson LM, Muralidharan SV, Green LC, Li Z, Gesner EM, Hansen HC, Keller UB, McLure KG, Nilsson JA. 
Proc Natl Acad Sci U.S.A. 2014:111(26):E2721-30.
  9. MTH1 inhibition eradicates cancer by preventing sanitation of the dNTP pool.
Gad Helge, Koolmeister Tobias, Jemth Ann-Sofie, Eshtad Saeed, Jacques Sylvain A, Ström Cecilia E, Svensson Linda M, Schultz Niklas, Lundbäck Thomas, Einarsdottir Berglind Osk, Saleh Aljona, Göktürk Camilla, Baranczewski Pawel, Svensson Richard, Berntsson Ronnie P-A, Gustafsson Robert, Strömberg Kia, Sanjiv Kumar, Jacques-Cordonnier Marie-Caroline, Desroses Matthieu, Gustavsson Anna-Lena, Olofsson Roger, et al [ Nilsson JA Nr. 53 ] Helleday Thomas. 
Nature 2014:508(7495):215-21.

  10. Antioxidants accelerate lung cancer progression in mice.
Sayin Volkan I, Ibrahim Mohamed X, Larsson Erik, Nilsson Jonas A, Lindahl Per, Bergo Martin O. 
Sci Transl Med2014:6(221):221ra15.





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Utskriftsdatum: 2017-11-23