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New insight into cancer mutations

News: Dec 04, 2014

Erik Larsson and his postdoc Johan Fredriksson (Inst of Biomedicine) has mined The Cancer Genome Atlas for cancer mutations outside of the human DNA sequences that code for proteins. They establish a new bioinformatical method to uncover associations between somatic mutations in regulatory regions and mRNA changes. They could confirming the existence of activating mutations in the promoter of the TERT gene in several cancer types. Furthermore, they also identified novel recurrent non-coding mutations in melanoma. In a collaboration with Sahlgrenska Translational Melanoma Group (SATMEG) investigators Jonas Nilsson and Lars Ny at the Sahlgrenska Cancer Center, they could confirm these mutations in tumor DNA from patients at the Sahlgenska University Hospital. The relevance of these novel mutations for melanoma development awaits further experimental validation.

The study is published in Nature Genetics and more information can be found here:


BY: Jonas Nilsson

Page Manager: Ulrika Lantz Carlsson|Last update: 3/13/2014

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