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Group Mikael Nilsson

Research summary

Thyroid dysgenesis and cancer are the most common developmental defects and tumors of the endocrine system. We investigate basic mechanisms of pathogenesis with the long-term attempt to identify new biomarkers and potential novel treatment strategies of these diseases. Particular interest is paid to inductive and supporting signals that regulate progenitor cell commitment, propagation of endocrine cell lineages, and differentiation of epithelial and hormonogenic phenotypes in normal cells, and the corresponding aberrations recognized in diseased cells.

Current work on embryos concerns expression and functional analysis of transcription factors (e.g. FoxA2) and morphogens (e.g. Sonic hedgehog) implicated in endoderm and neuroendocrine development of the thyroid gland; the potential role of candidate genes for the biology of thyroid cancer with different ancestral cell origins are coordinately addressed.

The involvement of ephrin-Eph receptor bidirectional signaling in post-natal thyroid growth is investigated in a model of experimental goitrogenesis. The DNA damage responses of the fetal and young thyroid to potentially carcinogenic levels of 131-I are characterized in mouse models under the influence of modifying genetic and environmental factors.

The potential use of kinase inhibitors to restitute iodide transport in thyroid tumors with blocked radioiodine uptake (e.g. by exaggerated/constitutive activation of the EGFR-Ras-MAPK pathway) is studied in cultured cells expressing the sodium/iodide symporter (NIS).

Research tools and resources

A combination of 3D-organotypic cell culture techniques and animal models is employed for cell and molecular biology and genetic studies. An isotope laboratory is at hand for investigation of radiobiology effects of radioiodine and other nuclides of interest.

Current group members

Mikael Nilsson, MD, PhD, Director/Group leader at Sahlgrenska Cancer Center and Professor of anatomy
Shawn Liang, Postdoc
Elin Schoultz, MD, PhD student
Therese Carlsson, Technician
Lina Qtet, MD student, Amanuens
Thomas Ramo, MD student, Amanuens

Selected publications

Group Mikael Nilsson publications on PubMed

Contact information

Mikael Nilsson

E-mail: Mikael Nilsson
Phone: +46 (0)31 786 3324

Visiting address:
Sahlgrenska Center
for Cancer Research,
Medicinaregatan 1F
413 90 Gothenburg

Page Manager: Yael Zukovsky Fitoussi|Last update: 5/15/2020

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