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Group Volkan Sayin

Research summary

Research on lung cancer and metabolomics, using mouse models.

The overarching goal of our research is to improve the quality of life and survival rates of cancer patients, guide personalized clinical trials, repurpose pre-existing drugs and to find novel combination therapies that can synergize with current standard of care therapies including chemo- and immune therapies.

Current group members

Volkan Sayin, PhD, Group leader
Kristell Le Gal Beneroso, PhD, Postdoc
Nadia Gul, PhD, Postdoc
Angana Patel, PhD Student
Ella Äng, MD, PhD Student
Jozefina Dzanan, PhD Student

Selected publications

  1. Activation of Oxidative Stress Response in Cancer Generates a Druggable Dependency on Exogenous Non-essential Amino Acids.
    LeBoeuf SE, Wu WL, Karakousi TR, Karadal B, Jackson SR, Davidson SM, Wong KK, Koralov SB, Sayin VI, Papagiannakopoulos T. Cell Metab. 2019 Nov 28. pii: S1550-4131(19)30619-9. doi: 10.1016/j.cmet.2019.11.012.
     
  2. Protein prenylation restrains innate immunity by inhibiting Rac1 effector interactions.
    Akula MK, Ibrahim MX, Ivarsson EG, Khan OM, Kumar IT, Erlandsson M, Karlsson C, Xu X, Brisslert M, Brakebusch C, Wang D, Bokarewa M, Sayin VI, Bergo MO. Nat Commun. 2019 Sep 4;10(1):3975. doi: 10.1038/s41467-019-11606-x.
     
  3. Targeting Metabolic Bottlenecks in Lung Cancer.
    Sayin VI, LeBoeuf SE, Papagiannakopoulos T. Trends Cancer. 2019 Aug;5(8):457-459. doi: 10.1016/j.trecan.2019.06.001. Epub 2019 Jun 27.
     
  4. BACH1 Stabilization by Antioxidants Stimulates Lung Cancer Metastasis.
    Wiel C, Le Gal K, Ibrahim MX, Jahangir CA, Kashif M, Yao H, Ziegler DV, Xu X, Ghosh T, Mondal T, Kanduri C, Lindahl P, Sayin VI, Bergo MO. Cell. 2019 Jul 11;178(2):330-345.e22. doi: 10.1016/j.cell.2019.06.005. Epub 2019 Jun 27.
     

More group Volkan Sayin publications on PubMed

 

Contact Information

Volkan Sayin

E-mail: Volkan Sayin

Visiting address:
Sahlgrenska Cancer Center
Medicinaregatan 1F
413 90 Gothenburg

Page Manager: Yael Zukovsky Fitoussi|Last update: 1/23/2020
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