Till startsida
University of Gothenburg
Sitemap
To content Read more about how we use cookies on gu.se

Group Yan Chen

Research summary

We have a longstanding interest in studying cooperative genetic alterations that perturb cell cycle restriction and program malignant transformation. Accordingly, we have developed the experimental models in which specific genetic alterations can be investigated in isogenic contexts.

In addition, we have used genetic tools (short hairpin RNA, CRISPR and open reading frame libraries) to identify and study oncogenes, cancer pathways and related targets. By applying these tools or methods, we are in the process to study and identify genes/molecules involved in tumorigenesis, tumor maintenance, and drug sensitivity or resistance.

Over the past several years, we have been particularly interested in using these approaches to identify synthetic lethal partners to oncogenes and tumor suppressors. In particular, we are focusing on oncogenic ras and its effector pathways. We identified several candidates that appear critical for cancer cells harboring oncogenic ras to survive. Currently, we are expanding and extending our initial studies into more complex experimental models that recapitulate further aspects of human cancers.

Research tools and resources

We are using primary and tumor cell lines, 3D/organoids as well as xenograft and genetically modified mouse models for cancer biology studies. A range of cellular and molecular biological techniques are being employed.

Group members

Yan Chen, MD, PhD
Yunyun Ma, MD, PhD
Qiang Zhang, MD, PhD

Selected publications

  1. Ganapathy G, Liu J, Xiong R, Yu T, Makriyannis A, Chen YC 2019 Chronic low dose arsenic exposure preferentically perturbs mitotic phase of the cell cycle. Genes & Cancer in press.
     
  2. Yu T, Ganapathy S, Shen L, Peng B, Kim SH, Makriyannis A, Chen YC 2018 Phellinus linteus extract is in synergy with camptothecin11 for inducing S phase crisis in colon cancer cells. Oncotarget 9: 6308.
     
  3. Ganapathy S, Li P, Lafontant J, Xiong R, Yu T, Zhang G, Chen YC 2017 Chromium IV expresure, via Src/Ras signaling, promotes tumorigenesis in human lung and skin cells. Toxicol Appl Pharm. 56: 1808.
     
  4. Choi B, Chen X, Chen YC, Dai W. 2016 WWP2 is required for normal cell cycle progression. Genes & Cancer 6: 371.
     
  5. Chen H, Guan R, Lei Y, Chen J, Ge Q, Dou R, Zhang X, Chen H, Qi X, Zhou X, Chen YC. 2015 Lymphangiogenesis in gastric cancer regulated through Akt/mTOR-VEGF-C/VEGF-D axis. BMC Cancer 15: 103.
     
  6. Zhou X, Kim SH, Shen L, Lee HJ, Chen YC. 2014 Activation of mitotic catastrophe in NF1 deficient cells by PKC inhibition. Cell Cycle 13: 2340.
     
  7. Nishioka T, Luo LY, Shen L, He H, Chen YC. 2014 Nicotine exposure increases the resistance of cancer cells to cisplatin through enhancing Bcl-2 stability. Bri J of Cancer 110: 1785.
     
  8. Shen L, Nishioka T, Guo J, Chen YC. 2012 Geminin functions downstream of p53 in v-K-ras-induced DHFR amplification. Cancer Res. 72: 6153.

     

Contact information

Chang Yan Chen

E-mail: Chang Yan Chen
Phone: +46 31 786 3870
+46 (0) 729 694915

Visiting address:
Sahlgrenska Cancer Center
Medicinaregatan 1F
413 90 Gothenburg

Page Manager: Yael Zukovsky Fitoussi|Last update: 3/25/2019
Share:

The University of Gothenburg uses cookies to provide you with the best possible user experience. By continuing on this website, you approve of our use of cookies.  What are cookies?